Dr. Gregory Wemhoff

Associate Professor of Biology gwemhoff@sf.edu

Bio

As an extension of my interest in immunology and cancer, I have an interest in investigating and expanding what is known regarding the role played by microRNAs in the generation of an effective immune response to cells which have become oncogenic. Additionally, I enjoy mentoring students to introduce them to basic research and establishing skills such as performing cell-based assays and learning aseptic technique.

As an instructor, my teaching philosophy and approach strive to raise students to a higher level of performance. I am primarily a facilitator and I look at this role in this way: Like many of us, I enjoy video games. I also enjoy football. So it may not be so surprising that I would acquire Madden Football. It comes with a very detailed manual, page after page of everything you need to know to utilize every aspect of the game. When I first acquired the game, I read the manual, beginning to end. However, when I sat down to play my son the first time (an experienced Madden fan), I turned to him to ask “how do you pass?” – he was my facilitator. With his insight I was an active participant much faster than I would have been if left to myself. It is my goal to get my students participating in their areas of interest as quickly as possible.

Areas of Interest

Immunology
Cancer
Stroke
Molecular Biology
Genetics

Patents

Ligand-Labeled Conjugates which Contain Polyoxyanions of Sulfur orPhosphorous. Patent No. 5,106,762.
Flow Immunosensor Method and Apparatus. Patent No. 5,183,740.
Flow Immunosensor Apparatus. Patent No. 6,245,296.

Publications

Meslin, F., Hamaï, A., Mlecnik, B., Rosselli, F., Richon, C., Jalil, A., Wemhoff, G., Thiery, J., Galon, J. Chouaib, S., 2011. hSMG-1 is a granzyme B-associated stress-responsive protein kinase. J. Molec. Med. 88(4): 411-421.
Wemhoff, G., Zenser, N., Malkov, D., Corman, C., Daley, L., Hibbs, S., Pegg, G., Spencer, A., Zakeri, H., Zhangn, Z., and Davis, G. 2011. Using Zinc Finger Nuclease Technology to Investigate Breast Cancer Ontogeny. BioScience Technology. 6: 18.
Whelan, J.P., A.W. Kusterbeck, G.A. Wemhoff, R. Bredehorst, and F.S. Ligler. 1993. Continuous-flow immunosensor for detection of explosives. Analytical Chemistry, 65; 3561-3565.
Wemhoff, G.A., S.Y. Rabbany, A.W. Kusterbeck, R.A. Ogert, R. Bredehorst, and F.S. Ligler. 1992. Kinetics of antibody binding at solid-liquid interfaces in flow. J. Immunol. Meth., 156; 223 – 230.

Selected Presentations

H. C. Paraiso, P-C. Kuo, J-H Yen, G. A. Wemhoff, R. D. Sweazey, F-L Chang, I-C Yu. Dimethyl fumarate modulates pro-inflammatory microglia activation via the nuclear-erythroid factor 2- independent and -dependent pathways. Neuroscience 2016. November 12-16, 2016, San Diego, CA
Wemhoff, G.A., Topalov, S., Hong-Goka, B., Sweazey, R., and Chang, F.L.. 2015. An investigation of the early cellular responses associated with an ischemic event: cortical and hippocampal profile of cellular markers EGFR, CD133, NeuN, and Nestin. Society for Neuroscience.
Robertson, F.M., Hibbs, S., Boley, K.M., Khoi Chu, K., Ye, Z., Wright, M.C., Liu, H., Luo, A.Z., Cristofanilli, M., Wemhoff, G. 2012. Zinc Finger Nuclease Genome Engineering Reveal Multiple Functions of Secretory Leukocyte Peptidase Inhibitor in Regulating Pleuripotency of Cancer Stem Cells in Inflammatory Breast Cancer. CTRC-AACR San Antonio Breast Cancer Symposium. Abstract: 851629.
Zhang, Z., Corman, C., Daley, L., Hibbs, S., Pegg, G., Zakeri, H., Davis, G., and Wemhoff, G. 2012. Investigation of Genetic Modified MCF10A Breast Epithelial Cell Lines Generated by ZFN Technology. Molec. Med TriCon. San Francisco, CA